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Recorded Delivery http://doctorlinder.com/amitriptyline-hydrochloride-50-mg-tablets-tezr amitriptyline withdrawal chest pain For metastatic brain tumors, the risk factors are those associated with the original cancer. “For instance, the cancer that most frequently spreads to the brain is lung cancer,” says Yong. “Since smoking is the main risk factor for lung cancer, it can also increase your risk of going on to develop a malignant brain tumor.”